A collection of videos from our organ-on-chip models and methods, from live imaging of the tissue to infection and perfusion on the biochip. The videos are grouped by model.
An animation showing how culture medium is guided through the biochip, along the vascular side of the organ-on-chip model.
A three-dimensional animation from a gut-on-chip colonised with Vibrio cholerae. The bacterial DNA is visualised by DAPI staining, and metabolically active bacteria appear in green through a GFP reporter gene.
Created by Dr. Zoltan Cseresnyes, Applied Systems Biology, Hans-Knöll-Institute Jena.
A gut-on-chip colonised with Candida albicans, shown in red, where the fungus forms microcolonies. The E-cadherin of the enterocytes is shown in green and the cell nuclei in blue by DAPI staining.
Created by Dr. Zoltan Cseresnyes, Applied Systems Biology, Hans-Knöll-Institute Jena.
A gut-on-chip showing the invasive hyphal growth of Candida albicans. The hyphae appear in blue and the pores of the membrane as dark circles. The recording is then translated into a three-dimensional model, in which the hyphae are rendered in green and the origins of hyphal growth as small white spheres.
Created by Dr. Zoltan Cseresnyes, Applied Systems Biology, Hans-Knöll-Institute Jena.
The gut-on-chip epithelium forming three-dimensional villus structures under continuous perfusion. The E-cadherin of the epithelial cells is shown in green and the cell nuclei in blue by DAPI staining.
Created by Valentin Wegner.
A three-dimensional model of a Candida albicans hypha growing through a pore in the membrane of the gut-on-chip.
Created by Dr. Zoltan Cseresnyes, Applied Systems Biology, Hans-Knöll-Institute Jena.
A lung-on-chip infected with Aspergillus fumigatus, showing the outgrowth of the fungal hyphae. The hyphal network is segmented by branching level for a morphometric analysis of hyphal growth and for an assessment of tissue invasiveness.
Created by Dr. Zoltan Cseresnyes, Applied Systems Biology, Hans-Knöll-Institute Jena.
A lung-on-chip in which macrophages track the conidia of Aspergillus fumigatus and remove them by phagocytosis.
Created by Dr. Zoltan Cseresnyes, Applied Systems Biology, Hans-Knöll-Institute Jena.
A liver-on-chip showing Staphylococcus aureus persisting in macrophages of the parenchymal tissue. The macrophages are shown in red, bacteria on the outer surface of the macrophages in turquoise, and bacteria persisting in the cytosol as small spheres in magenta.
Created by Dr. Zoltan Cseresnyes, Applied Systems Biology, Hans-Knöll-Institute Jena.
Select a video to play it. The models shown here are described in more detail on the chip platform page and in our research overview.